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Yoshihisa Sugimura Selected Research

Neurogenic Diabetes Insipidus (Central Diabetes Insipidus)

1/2022Studies on anti-rabphilin-3A antibodies in 15 consecutive patients presenting with central diabetes insipidus at a single referral center.
1/2021Lymphocytic infundibuloneurohypophysitis with positive anti-rabphilin-3A antibodies nine years post-onset of central diabetes insipidus.
3/2018Cullin-associated NEDD8-dissociated protein 1, a novel interactor of rabphilin-3A, deubiquitylates rabphilin-3A and regulates arginine vasopressin secretion in PC12 cells.
1/2018Critical role of rabphilin-3A in the pathophysiology of experimental lymphocytic neurohypophysitis.
6/2017Usefulness of anti-rabphilin-3A antibodies for diagnosing central diabetes insipidus in the third trimester of pregnancy.
12/2004Novel mutant vasopressin-neurophysin II gene associated with familial neurohypophyseal diabetes insipidus.

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Yoshihisa Sugimura Research Topics

Disease

12Hyponatremia
01/2021 - 03/2005
6Neurogenic Diabetes Insipidus (Central Diabetes Insipidus)
01/2022 - 12/2004
6Autoimmune Hypophysitis
01/2022 - 07/2015
5Demyelinating Diseases (Demyelinating Disease)
11/2014 - 03/2005
4Inappropriate ADH Syndrome (SIADH)
01/2021 - 04/2004
4Body Weight (Weight, Body)
11/2019 - 04/2016
3Insulin Resistance
11/2019 - 08/2004
3Polyuria
06/2017 - 12/2004
3Diabetes Insipidus
06/2017 - 02/2010
3Inflammation (Inflammations)
02/2017 - 10/2013
2Adrenal Insufficiency (Adrenal Gland Hypofunction)
01/2017 - 10/2013
2Dehydration (Water Stress)
12/2014 - 02/2012
2Osteoporosis
03/2011 - 03/2010
2Congenital Abnormalities (Deformity)
01/2009 - 05/2008
1Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
05/2022
1Vision Disorders (Hemeralopia)
04/2022
1Uveitis
04/2022
1Pancreatitis
02/2022
1Hypertriglyceridemia
02/2022
1Ketosis
02/2022
1Germinoma
01/2022
1Sarcoidosis (Schaumann Disease)
01/2022
1Frailty
01/2022
1Hemolysis
04/2021
1HELLP Syndrome
04/2021
1Acute fatty liver of pregnancy
04/2021
1Weight Gain
01/2021
1Memory Disorders (Memory Loss)
01/2021
1Graves Disease (Basedow Disease)
02/2020
1Type 2 Diabetes Mellitus (MODY)
11/2019
1Hyperinsulinism (Hyperinsulinemia)
05/2019
1Combined Pituitary Hormone Deficiency
03/2017
1Cognitive Dysfunction
03/2016
1Hypophysitis
07/2015
1Intracranial Hemorrhages (Intracranial Hemorrhage)
11/2014
1Obesity
10/2013
1Neoplasms (Cancer)
10/2013
1Congenital adrenal hyperplasia due to 21 hydroxylase deficiency
10/2013
1Neural Tube Defects (Exencephaly)
01/2009

Drug/Important Bio-Agent (IBA)

12Vasopressins (Vasopressin)IBA
01/2021 - 04/2004
6AntibodiesIBA
01/2022 - 07/2015
5Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric
01/2021 - 03/2005
5SodiumIBA
01/2021 - 07/2006
5Arginine Vasopressin (Argipressin)IBA
01/2018 - 04/2004
4GlucocorticoidsIBA
03/2017 - 03/2005
3ElectrolytesIBA
01/2022 - 03/2016
3Messenger RNA (mRNA)IBA
02/2017 - 03/2011
3CytokinesIBA
03/2011 - 04/2004
2SteroidsIBA
04/2022 - 10/2013
2EnzymesIBA
04/2021 - 10/2013
2Insulin (Novolin)FDA Link
11/2019 - 05/2019
2Glucose (Dextrose)FDA LinkGeneric
11/2019 - 08/2004
2Minocycline (Cyclops)FDA LinkGeneric
11/2014 - 12/2010
2Dexamethasone (Maxidex)FDA LinkGeneric
07/2006 - 03/2005
1placental alkaline phosphataseIBA
05/2022
1Tumor Biomarkers (Tumor Markers)IBA
05/2022
1SugarsIBA
02/2022
1Vasopressin Receptors (Arginine Vasopressin Receptor)IBA
01/2021
1Immunoglobulins (Immunoglobulin)IBA
02/2020
1CarbohydratesIBA
11/2019
1Starch (Cornstarch)IBA
05/2019
1Risedronic Acid (Actonel)FDA LinkGeneric
01/2019
1AutoantigensIBA
03/2018
1Rabphilin-3AIBA
03/2018
1Cystinyl AminopeptidaseIBA
06/2017
1Dinoprostone (PGE2)FDA Link
06/2017
1Interleukin-10 (Interleukin 10)IBA
02/2017
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
01/2017
1Memantine (Namenda)FDA Link
01/2017
1NeuropeptidesIBA
04/2016
1Agouti-Related ProteinIBA
04/2016
1Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
04/2016
1Transcription Factors (Transcription Factor)IBA
12/2014
1Antidiuretic Hormone Receptor AntagonistsIBA
11/2014
1TolvaptanFDA Link
11/2014
1gamma-Aminobutyric Acid (GABA)IBA
10/2013
1Pro-Opiomelanocortin (Proopiomelanocortin)IBA
10/2013
1Steroid 21-Hydroxylase (21 Hydroxylase)IBA
10/2013
1Testosterone (Sustanon)FDA Link
10/2013
1Hydrocortisone (Cortisol)FDA LinkGeneric
10/2013
1Oxidoreductases (Dehydrogenase)IBA
10/2013
1Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
10/2013
1Mixed Function Oxygenases (Monooxygenases)IBA
10/2013
1Ascorbic Acid (Vitamin C)FDA LinkGeneric
03/2011
1Nerve Growth Factors (Neurotrophins)IBA
03/2011
1Proteins (Proteins, Gene)FDA Link
03/2011
1Matrix Metalloproteinases (MMPs)IBA
03/2011
125-hydroxyvitamin DIBA
03/2010
1hydroxide ionIBA
03/2010
1DiureticsIBA
03/2010
1HomocysteineIBA
01/2009

Therapy/Procedure

2Therapeutics
04/2022 - 07/2006
1Hormone Replacement Therapy (Therapy, Hormone Replacement)
04/2022
1Activities of Daily Living (ADL)
01/2022
1Carbohydrate-Restricted Diet (Low Carbohydrate Diet)
11/2019
1Cardiopulmonary Resuscitation (CPR)
11/2019
1Protein-Restricted Diet (Diet, Protein Restricted)
05/2019
1Adrenalectomy
01/2017
1Aftercare (After-Treatment)
01/2017
1Infusion Pumps (Infusion Pump)
11/2014